Here is a pair of socks I adaped from Vogue Socks II. Not quite so many colour changes as the original pattern and I went to a regular interval shift in the main body to keep my head clear: 4 rows main colour, 2 rows accent colour, repeat going through rotation of 4 accent colours. Number of rows rotations worked out perfectly for a Medium sized sock.
The yarn is my own sport weight 100% Columbia lamb from our farm. It is very very soft but strength and softness are sometimes mutually exclusive so to be safe I knit wooly nylon, in the closest colour match, into the heels and toes.

The colours were pot dyed with Washast Acid Dyes: Lilac, Key Lime, Raseberry Sorbet, Saffron, Turquoise, and Bright Orange.
The top is a double hem, done in a 2:1 mock rib with a pico edge.

In this picture I've turned one sock inside out so you can see the colour joins. On the CSM (ciruclar sock machine) I cut the yarn colour I'm guitting, leaving a 4" tail. I pull that tail through the yarn carrier to the work side and lay it backwards under the latchhooks of the needles that have just finished knitting. I feed the new colour through the yarn carrier, and through the loop made by folding the old colour backwards, and lay the first few inches of the new colour forwards under the latches of the needles that will knit next. With this little trick there are no ends to sew in - they are knit-in as I go. Imagine having to sew all these ends in!
This method gives a precise colour change as each colour only overlaps on itself. This also gives an area of about 10 stitches where the yarn is double thickness. For this reason I did all my colour changes on the sole of the foot. With so many changes in this pattern it has the effect of creating a cushion sole!
I use a lot of self patterning yarns and one thing that drives me crazy is when there is a knot - which always signals an interuption in the pattern and sometimes even a complete change in direction of pattern. Manually changing the colours is certainly more labour intensive, but satifies my OCD need to 2 socks to perfectly match ;o)